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Chemicals in Grape Seed Extract Halts Colorectal Tumor Growth, Research Shows

According to a study that was published in the October 18, 2006 issue of Clinical Cancer Research, grape seed extract was shown to slow the growth of colorectal tumors on both mice and cell cultures.

The anti-cancer effects of grape seed extract on other types of tumors have been demonstrated in previous studies. Within the skin and seeds of grapes are antioxidant flavonoids that remove harmful free radicals from cells called proanthocyanidins. 

Researchers discovered an inhibition of cell growth that was dose and time dependent after the grape seed extract was exposed to two different kinds of human carcinoma cells. For live cancer cells that were exposed for the longest time -which was about two days – a 92 percent decrease was evident when given the highest dose.

Studies on mice were then conducted which showed a reduction of advanced colorectal tumors by 44 percent. The method by which grape seed extract inhibits cancer growth was also demonstrated for the first time during this study. Apparently, a critical protein called Cip1/p21 – which effectively freezes the tumor cell cycle, and can initiate the self destruction of a cancer cell – becomes increased with grape seed extract.

In fact, after 12 hours of treatment, the amount of Cip1/p21 protein within the cells increased 150 times. The longer the treatment time, the more cancer cells were frozen before they had a chance to divide.

Next on the agenda for the researchers is to figure out the lowest effective dose, and the highest non-toxic doses for grape seed extract used on mice.

Frank Mangano’s commentary:

Grape seed extract in my opinion, is one of the best cancer fighting anti-oxidants money can buy. It’s jam packed with disease fighting compounds like resveratrol, which has been sited in many studies to provide a number of different benefits to the body.

This is a promising study and I’m not surprised to read about yet another benefit of grape seed extract. Grape skin and seeds are a rich source of antioxidant flavonoids called proanthocyanidins.

I’m an advocate of Grape seed as it improves the stability of collagen and elastin, two substances that are crucial for healthy skin, joints, ligaments, tendons and blood vessels. Grape seed is also used to improve microcirculation throughout the body.

Grape seed extract may also help to prevent and treat heart diseases such as high blood pressure and high cholesterol, according to human case reports and results from some laboratory and animal studies. 

You can find grape seed extract in capsule form at your local health food store but remember, to truly shield your body from cancer most effectively, it’s essential that you control your insulin levels, get sufficient amounts of omega-3 fats, get safe amounts of natural sunlight to normalize your vitamin D levels and make exercise a part of your regimen 3 to 4 times a week.

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